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சுருக்கம்

The Effect of Postoperative Early Lumbar Drainage on Delayed Fever after Cerebellopontine Angle Tumor Surgery: Study Protocol for a Randomized Controlled Trial

Tianzhi Zhao

Background: Postoperative fever is one of the common complications in neurosurgery; intracranial aseptic inflammation and infection are important incentive factors. Continuous drainage of CSF via Lumbar Drainage (LD) is often used in the treatment of postoperative intracranial infection or aseptic inflammation. Compared with the previously reported placement of the LD after the onset of meningitis symptoms, we designed this Randomized Controlled Trial (RCT) to evaluate the effectiveness and safety of early drainage (1st day post-operation) of Cerebrospinal Fluid (CSF) using the preset lumbar cistern to prevent delayed fever or reduce its treatment time after Cerebellopontine Angle (CPA) tumor surgery.

Methods: Patients suffering from CPA tumor and completed resection of the tumor with intraoperative dura opening time>4 h are being recruited for this study. The study is a 2-arm RCT to compare an intervention group receiving postoperative early LD and standard postoperative care to a control group receiving standard postoperative care only. Duration of fever in patients with delayed fever after operation, as the main outcome, will be contrasted in the two groups.

Discussion: Here, we present the study design of a prospective RCT to evaluate the safety and efficacy of using preoperative preset LD to treat or reduce of postoperative delayed fever.