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Is it Time to Consider Use of Levo-methadone (R-(-)-Methadone) to Replace Racemic Methadone?

Philip Lisberg and Feodor Scheinmann

Racemic methadone, a mixture of its two enantiomeric optically active forms, R-(-)-Methadone and S-(+)-Methadone (also known as levo-methadone and dextro-methadone), was first synthesized in Germany before the outbreak of World War II.