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Comparative Efficacy of Newcastle Disease’s Live Vaccines in Broilers Using Hemagglutination Inhibition (Hi) Test at Jaba Mansehra

Naqash Khalid1*, Aisha Bakhtiar2, Sardar Azhar Mehmood2, Hajira Mehmood2, Syeda Faryal Sakhawat2, Zainab Arshad2, Zanib Miskeen2, Muhammad Ayaz1

Two commercial Lasota strain Newcastle Disease (ND) vaccines namely Lasota vaccine-1 and vaccine-2 and two Mukteswar Newcastle disease vaccines namely Mukteswar vaccine-1 and vaccine-2 were evaluated fort their efficacy and influence on productive performance of broilers. For this purpose, total of 75 broilers day-old chicks were distributed into five equal groups tagged as A, B, C, D and E respectively, each group was further divided into 3 subgroups containing 5 birds per subgroup respectively. The birds in groups B, C, D and E were actively immunized against ND with Lasota-1, Lasota-2, Mukteswar-1 and Mukteswar-2 respectively, on days 10 and 21 through ocular route, leaving A as control group leaved unvaccinated. The serum HI antibody response to these four vaccines was determined on day 21^st and 35^th day of the experiment. According to the recorded results, group C vaccinated with Lasota (vaccine-2) showed significantly high (p<0.05) antibody titers throughout the experiment as an evidence of its high efficacy. Other performance parameters such as feed intake, water intake, total body weight and Feed Conversion Ratio (FCR) were recorded on day 7^th, 14^th, 21^st and 35^th day of the experiment. These performance parameters differed significantly (p<0.05) throughout the study period. The unvaccinated broilers (control group) showed better results in terms of weight gain and FCR than the vaccinated groups and there were not found a noticeable difference in the productive performance of the broilers between the vaccinated groups. From the recorded results, it was concluded that group C of broilers administered with Lasota vaccine-2 proved to be more efficient in terms of antibody production in broilers, although all the tested vaccines produced protection titers and unvaccinated broilers had better productive performance as compared to vaccinated flock.