ஐ.எஸ்.எஸ்.என்: 2379-1764
Zhongfei Han, Nino Rcheulishvili, Dimitri Papukashvili, Xin Hao and Changjin Zhu
Aldose reductase (ALR2) plays a pivotal role in the development of diabetic complications. ALR2 inhibitors (ARIs) have proven efficient to prevent and delay the chronic diseases, and thus attracted significant research interest. This article reviews a series of aromatic heterobicyclics-based ARIs developed over recent years, and discusses about their structure-activity relationships as well as their multifunctionalities such as antioxidant property