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P-Selectin is a Key Molecule Underlying the Pathophysiology of Aspirin- Exacerbated Respiratory Disease

Chihiro Mitsui1, Keiichi Kajiwara, Hiroaki Hayashi, Jun Ito, Haruhisa Mita, Emiko Ono, Noritaka Higashi, Yuma Fukutomi, Kiyoshi Sekiya, Takahiro Tsuburai, Kazuo Akiyama, Kazuhiko Yamamoto and Masami Taniguchi

Recently, the evidence for platelet association with allergic diseases has been established by many researches. Activated platelets contribute to airway hyper reactivity, bronchoconstriction, airway inflammation and airway remodeling in asthmatic patients. We aimed to clarify platelet activation and key molecules on platelets, which are mainly associated with the mechanism underlying aspirin-exacerbated respiratory disease.