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Prognostic Factors in Patients with Well-Differentiated Thyroid Carcinoma with Locoregional Recurrence Submitted for Salvage Treatment

Bernardo Fontel Pompeo, ThiagoCelestino Chulam, Ana Lucia Noronha Francisco and Luiz Paulo Kowalski

Background: Well-differentiated thyroid carcinoma is characterized by an excellent prognosis; however, recurrence rates range from 5% to 23%, and mortality after salvage treatment ranges from 38% to 69%.

Objectives: To identify prognostic factors in patients who have undergone salvage therapy for well-differentiated thyroid carcinoma.

Patients and methods: This is a retrospective cohort series including 102 patients with respectable locoregional recurrences who underwent salvage treatment. One hundred twenty loco-regional recurrences were observed amongst 102 patients. Univariate survival analysis was performed using the Kaplan-Meier method.

Results: Five-year overall survival rates were significantly associated with age over 45 years (67.6%) (p <0.0001), site of recurrence (local or regional recurrence and distant metastasis (65.8%), only local recurrence (88.8%), only regional recurrence (92.2%) (p=0.0267), and histology (papillary carcinoma (90.3%) and follicular carcinoma, (72.2%) (P=0.0156).

Conclusion: Age over 45 years, follicular carcinoma and location of recurrence were significant prognostic factors in patients with well-differentiated thyroid carcinoma who underwent salvage treatment.