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Mixed Adenoneuroendocrine Carcinoma in the Transverse Colon: An Infrequent Neoplasm in an Unusual Location

Cristina Sánchez Cendra, Beatriz Antón Pascual, Beatriz Losada Vila, Maria del Carmen Pantín Gonzalez, Javier de la Rubia Maestu, Ignacio Juez Martel and Rocío S Cardozo Rocabado

Mixed adenoneuroendocrine carcinoma (MANEC) is a rare tumor of the gastrointestinal tract that consists of a dual adenocarcinomatous and neuroendocrine differentiation. Frequently only one component is identified, leading to incomplete diagnosis and suboptimal treatment. This kind of tumors therefore constitutes a diagnostic challenge. They represent a minority of gastrointestinal neoplasms, being more frequent in the stomach, gallbladder and pancreas. Only a hundred cases have been described in the colon, and specifically only 6 cases in the transverse colon have been published in the English literature.