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Mechanism of Ozone Alleviation of Malignant Ascites in Hepatocellular Carcinoma through Inhibition of NETS

Feng Han, Jiayou Guo, Mingchen Mu, Ka Bian, Zhenting Cui, Qiong Duan, Jianxin Ma*, Lai Jin*, Wentao Liu*, Fanghong Chen*

Malignant ascites in hepatocellular carcinoma is usually a sign of advanced disease and poor prognosis and is also thought to be associated with chronic inflammation mediated by Neutrophil Extracellular Trap-networks (NETs). Whereas ozone, a strong oxidant, has significant antibacterial and anti-inflammatory effects, its effectiveness in treating malignant liver ascites is unclear. cOzone showed significant anti-peritoneal fluid production properties in H22 tumor-bearing mice, and ozone reduced peritoneal fluid production by activating AMPK and up-regulating SR-A phagocytosis Damage-Associated Molecular Patterns (DAMPs) to reduce the production of NETs. This suggests that ozone could be used as a new drug for the treatment of malignant ascites in hepatocellular carcinoma.