பூஞ்சை மரபியல் & உயிரியல்

பூஞ்சை மரபியல் & உயிரியல்
திறந்த அணுகல்

ஐ.எஸ்.எஸ்.என்: 2165-8056

சுருக்கம்

In Vitro Potency of Combinatorial Antifungal Drugs towards Candida Isolates from Patients

Sakshi Agarwal, Smitanjali Parida, Bhuvnesvri Jadoun, Shreya N Patel, Sumit Moolchandani, Himanshu Puniyani, Raviranjan Kumar Pandey, Mandvi Mathur, Sandeep K Shrivastava, Aakanksha Kalra*

Candidiasis is a fungal infection (mycosis) caused by an opportunistic yeast with only 8-10 pathogenic species. In spite of the multiple classes of antifungal drugs available to combat these infections, the treatment is hampered by drug toxicity, tolerability, emergence of drug resistant isolates and many more. Combination therapy has been suggested as a possible approach to improve these treatment outcomes. This study is, therefore, aimed at the analysis of the sensitivity of Candida isolates obtained from patients towards different classes of drugs affecting multiple pathways in the pathogen life cycle. Four different individual drugs with different mechanisms of action and six different combinations of these drugs at three different proportions (1:1, 1:3, and 3:1) were used for the study. All the drug sensitivity assays were performed by the agar well diffusion method. The results were statistically analyzed using Prism software. Results have shown synergistic effects of drug combinations on the sensitivity of the isolates without much variation in the stoichiometric ratios, thereby providing an alternative to monotherapy to combat the emergence of drug resistant isolates and drying existing drug pipelines.

மறுப்பு: இந்த சுருக்கமானது செயற்கை நுண்ணறிவு கருவிகளைப் பயன்படுத்தி மொழிபெயர்க்கப்பட்டது மற்றும் இன்னும் மதிப்பாய்வு செய்யப்படவில்லை அல்லது சரிபார்க்கப்படவில்லை.
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