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சுருக்கம்

The Relationship between Uric Acid and Hypertension in Adults in Fako Division, SW Region Cameroon

Jules Clement Nguedia Assob, Marcelin Ngowe Ngowe, Dickson Shey Nsagha, Anna Longdoh Njunda, Yvonne Waidim, Dieudonné Njimoh Lemuh and Elroy Patrick Weledji

Uric acid has been associated with hypertension in many studies involving different populations but little or no information was found on this association in a Cameroonian population. The aim of this study therefore was to correlate serum uric acid concentrations with blood pressure measurements in individuals who are hypertensive, pre-hypertensive and normotensive, and to investigate the possibility of existence of an association between uric acid levels and other risk factors for hypertension. A total of 297 adults from Fako Division participated in the study. Blood pressure, serum uric acid, fasting blood glucose (subjects with ≥ 110mg/dl were excluded), lipids, body mass index and waist circumference were measured. Individuals who were pre- hypertensive had the highest mean uric acid concentration which was significantly higher than that for normotensives (P<0.0001). There was a significant positive correlation between uric acid with systolic and diastolic blood pressure (P<0.0001; P<0.0001), respectively. A significant positive correlation was also observed between serum uric acid levels with gender, age, triglycerides and life style patterns (P<0.0001). However, adjusting for these confounders did not change the increasing trend observed between serum uric acid with both systolic and diastolic blood pressure.