ஆர்கானிக் கெமிஸ்ட்ரி: தற்போதைய ஆராய்ச்சி
திறந்த அணுகல்

சுருக்கம்

Synthesis, Characterization and In Vitro Antitumor Evaluation of New Pyrazolo[3,4-d]Pyrimidine Derivatives

Ahmed M El-Morsy, Mohamed S El-Sayed, Hamada S Abulkhair

A new series of 3-(methylthio)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine derivatives was synthesized. The antitumor activity of this series against human breast adenocarcinoma cell line MCF7 was evaluated. Out of twenty new derivatives, ten were revealed mild to moderate activity compared with doxorubicin as a reference antitumor. Among this new series N-(2-chlorophenyl)-2-(3-(methylthio)-4-oxo-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-5(4H)-yl)acetamide (13 a) was found the most active one with IC50 equal to µM.