ஜர்னல் ஆஃப் குரோமடோகிராபி & பிரிப்பு நுட்பங்கள்
திறந்த அணுகல்

சுருக்கம்

Quantification of Newer Anti-Cancer Drug Clofarabine in their Bulk and Pharmaceutical Dosage Form

Brijesh D Patel, Usmangani K Chhalotiya and Dhruv B Patel

Quantitative determination of Clofarabine in their Pharmaceutical Dosage form was carried out by Liquid chromatographic method. The aim of the present work was to develop a RP-HPLC method for Clofarabine (CFB). The column used was Luna C-18 column (250 mm × 4.6 mm id, 5 m particle size) using Water: Methanol (60:40 v/v) as a mobile phase at a flow rate of 1.0 ml/min. Quantification was achieved with UV detection at 266 nm over the concentration range 0.05-20 μg/ml and % recovery was found to be in the range of 99.58-100.95 for CFB by the RPHPLC method. The proposed method was validated with respect to linearity, accuracy, precision, selective, sensitive and robustness. The method was fruitfully applied for the estimation of clofarabine in injection dosage forms.