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திறந்த அணுகல்

சுருக்கம்

PDT approach to treat early-stage invasive cervical cancer

Alexander Dushkin

Cervical cancer is a significant disease in female oncology. Photodynamic therapy (PDT) is a non-invasive procedure for treatment and prevention of the cervical papillomavirus infection clinical manifestations (ex. ICC – invasive cervical cancer). 18 patients with ICC IA-B stages have treated by PDT since 2016. In these case reports were included two most significant clinical cases of ICC treatment. These patients (33 and 43 y.o.) had ICC IAI and IBII stages. 1 patient (37 y.o.) had cancer in situ (CIS). It is a unique case. Visual changes of cervical surface looked like invasive tumor. Patients with ICC IAI stage and CIS had 1 PDT session. Patient with ICC IBII stage had three PDT session. PDT session included two steps. Photosensitizer (Chlorine E6) used for intravenously injection. After three hours the first step irradiation was started of the cervical canal (endocervix). The second step was polypositional (4 areas) irradiation of the cervical surface. Diagnosis was approved by magnetic resonance imaging (MRI) Digene-test, colposcopy and liquid-based cytology (LCB) or histological investigation. All patients had control check-up (MRI, Digene-test, colposcopy and LCB) no less than 3 times (on the 3rd, 6th and 12th months after PDT).

The PDT approach has an impressive result in treatment of cancerous lesions. Patient with ICC IBII managed to avoid the radical trachelectomy and save fertility. She had operative labour after 4 year of PDT. Patient with ICC IBII, patients with ICC IAI and CIS have no relapse during 5; 2,5 and 2,5 years respectively.