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Monocyte Count/HDL Cholesterol Ratio Is Associated With the Severity of Coronary Artery Disease

Mehmet Cosgun, Gülali Aktaş, İsa Sincer and Yılmaz Güneş

Objective: To examine the association between complete blood count parameters and severity of Coronary Artery Disease (CAD) in patients who underwent coronary angiography.

Methods: From October 2018 to February 2019, a total of 437 patients who had anginal symptoms and underwent coronary angiography were included in this study. Patients were divided into two groups according to their angiography findings; as significant CAD group (n=243) and non-significant CAD group (n=194). Patients’ baseline clinical characteristics and laboratory data including complete blood count parameters were recorded and compared between the groups.

Results: According to univariate analysis; White Blood Cell (WBC) count, neutrophil (NEU) count, Monocyte/ Lymphocyte Ratio (MLR), Neutrophil/Lymphocyte Ratio (NLR) and monocyte count/HDL cholesterol ratio (MHR) were detected to be significantly higher in significant CAD group as compared with non-significant CAD group. Multivariate logistic regresion analysis revealed that among laboratory parameters only MHR was found to be a significant and independent predictor of severity of CAD.

Conclusion: Our study demonstrated that MHR could be used as a novel biomarker for the prediction of the severity of CAD.