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Effect of Sesamum indicum L. Seed Oil Supplementation on the Kidney Function Parameters of Hypercholesterolemic Rats

Ajayi Olubumi B, Akomolafe SF, Malachi Oluwaseyi I and Oyerinde Adebowale S

Twenty four male rats weighing between 120-130 g were randomly assigned into four groups. Group A was fed normal diet; Group B, C and D were fed hypercholesterolemic diet (i.e. 20% fat + 1% cholesterol) for two weeks to establish hypercholesterolemia. Thereafter, Group B were maintained on hyper diet, while C and D were fed 5% and 10% Sesamum indicum oil supplemented diet for four weeks. Plasma was collected and analyzed for the activity of alkaline phosphatase (ALP) and concentrations of urea, creatinine, sodium, and potassium. The kidney was removed, decapsulated, weighed, homogenized, centrifuged and ALP activity was determined inthe supernatant. Significant increase (P<0.05) was observed in the activities of alkaline phosphatase in the kidney and serum and also in concentrations of urea, creatinine, sodium, potassium of the hypercholesterolemic rats compared to the normal control. Supplementation with Sesamum indicum seed oil at 5% and 10% levels resulted in significant decrease (P<0.05) in the activity of alkaline phosphatase and concentrations of urea, creatinine, sodium, and potassium. The implications of this result are highlighted.