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Effect of Curcumin on IL-6 and IL-8: A Meta-analysis and Systematic Review

Suocheng Hui, Kai Liu, Xiaohui Zhu, Chao Kang and Man-Tian Mi

Background and objectives: Studies that have investigated the effects of curcumin on the levels of IL-6 and IL-8 are controversial. We performed this meta-analysis to quantitatively evaluate the effects of curcumin on IL-6 and IL-8 regulation.
Methods and study design: The PubMed, Embase, and Cochrane Library (updated to March 2017) databases were searched for related studies. The pooled effects of curcumin treatment on IL-6 and IL-8 were evaluated using a random-effects model. Nine studies comprising a total of 512 subjects were included in the current meta-analysis.
Results: The overall outcome of this meta-analysis suggested that curcumin had no favorable effects on the concentration of IL-6 (-0.80 pg/mL; 95% CI, -1.61 to 0.01 pg/mL; P=0.052). Compared with control subjects, subjects treated with curcumin did not show a significant decrease in the concentration of IL-8 (-0.20 pg/mL; 95% CI, -1.02 to 0.62 pg/mL; P=0.639). Subgroup analysis further confirmed that the overall effects of curcumin on the concentrations of IL-6 and IL-8 were not notably affected by the dose or intervention duration of curcumin. Meta-regression analyses did not indicate dose effects of curcumin on IL-6 and IL-8.
Conclusion: This meta-analysis suggested that treatment of curcumin did not significantly reduce the concentrations of IL-6 and IL-8.