கணையக் கோளாறுகள் மற்றும் சிகிச்சை
திறந்த அணுகல்

சுருக்கம்

மருந்தினால் தூண்டப்பட்ட கடுமையான கணைய அழற்சி நேர்மறையான மறு-சவால் மூலம் உறுதிப்படுத்தப்பட்டது

நீலா ஃபதால்லா, ரௌதா ஸ்லிம், சோஃபியன் லரிஃப், ஹௌஸெம் ஹ்மௌடா, ஜபல்லா சக்ரி மற்றும் சேகர் பென் சேலம்

Drug-induced pancreatitis is a rare but severe adverse drug reaction with an incidence of 0.1-2%. More recent reports have estimated an incidence of up to 5%. Over 500 medications have been associated with this disease. Recrudescence of pancreatotoxicity upon re-exposure to the suspicious drug is considered the more reliable evidence of drug-induced pancreatitis. A retrospective review of MEDLINE was conducted to assess clinical outcomes of positive drug re-challenge following possible drug-induced pancreatitis. A total number of 250 cases of drug-induced pancreatitis with positive re-challenge were identified, among which, 183 met inclusion criteria for analysis in our review. A broad spectrum of suspect drugs was identified. Analgesics and anti-inflammatory drugs were incriminated in 30% of all cases, antibacterials in 18.6%, and cardiovascular agents in 10.9% of cases, immunomodulators in 11% of cases and gastro-intestinal drugs in 4.9% of cases. Improved identification and communication of possible drug-induced pancreatitis is needed to avoid potentially serious and/or fatal drug rechallenges.