ஜர்னல் ஆஃப் கிளினிக்கல் & எக்ஸ்பெரிமென்டல் டெர்மட்டாலஜி ரிசர்ச்
திறந்த அணுகல்

சுருக்கம்

Toxicoderma Secondary to 5-Fluorouracil: Differential Diagnosis of Paraneoplastic Pemphigus

Olga Martínez-Sáez, Eva Hermosa-Zarza, Alfredo Carrato and Reyes Ferreiro Monteagudo

We present the case of a patient undergoing chemotherapy with 5-Fluorouracil (5-FU), irinotecan and cetuximab, who presented polymorphous skin lesions with oral and genital mucosal involvement. The differential diagnosis included paraneoplastic pemphigus, a severe autoimmune disease associated with neoplasms. The histology can be variable with acantholysis or lichenoid dermatitis. The presence of circulating antibodies supports the diagnosis. In our case, the anatomopathological and immunological findings and the clinical improvement after the suspension of 5-FU confirmed that it was toxicoderma secondary to the latter.