ஜர்னல் ஆஃப் ஹெமாட்டாலஜி & த்ரோம்போம்போலிக் நோய்கள்
திறந்த அணுகல்

சுருக்கம்

The Importance of Altered Hematopoietic Microenvironmental Regulation in Chronic Myeloproliferative Disorders

Ahmad Reza Rahnemoon

Normal hematopoiesis depends on critical interactions that occur between stem cells and their microenvironment. This microenvironment is a complex meshwork composed of growth factors, stromal cells, and the extracellular matrix. Pluripotent Stem Cells (PSCs) are the stem cells which present in Chronic Myeloproliferative Disorders (CMPD) to have self-renewal capacity and towards differentiated cells in blood cells lineages. When the process of these stem cells become deregulated, neoplasm can result with possibly several mutations as well as the alterations in the control of growth factors and meanwhile disrupt the normal HSC function and blood cell production. Thus, these interactions must important in the pathogenesis and clinical expression of hematopoietic malignancies in humans. Here, I review the leukemic hematopoietic microenvironment and the genetic alterations as well.