ஜர்னல் ஆஃப் கிளினிக்கல் & எக்ஸ்பெரிமென்டல் டெர்மட்டாலஜி ரிசர்ச்
திறந்த அணுகல்

சுருக்கம்

Survival Analysis of Scalp Angiosarcoma Patients for Treatment Modalities in our Hospital Over the Past 28 Years

Erika Ito, Motoki Nakamura, Shoichi Watanabe and Akimichi Morita

Background: Angiosarcoma is a malignant neoplastic disease that often occurs in older people. The prognosis is poor and treatment effectiveness remains controversial.

Objective: We examined cases of scalp angiosarcoma treated in Nagoya City University Hospital from 1985 to 2013 and retrospectively analyzed treatment effectiveness.

Methods and materials: We identified 21 scalp angiosarcoma patients and followed up 18 patients among them. Disease-specific survival was calculated by the Kaplan and Meier method and compared between treatments.

Results: Median patient age was 75 years, and 14 patients (78%) were over 70 years of age. The 2- and 5-year disease-specific survival was 62.7% and 26.3%, respectively. Overall survival was significantly longer in those receiving radiotherapy or combination therapy with radiotherapy and chemotherapy. Thirteen patients (72%) received chemotherapy and 12 patients received taxane-based chemotherapy. Although toxicity occurred in 11 patients receiving taxane-based chemotherapy, most cases were grade 1 or 2.

Conclusions: Combination therapy with radiotherapy and taxane-based chemotherapy may be an effective medical treatment for scalp angiosarcoma, and can be performed safely even in older patients