மருந்தியல் பகுப்பாய்வு வேதியியல்: திறந்த அணுகல்
திறந்த அணுகல்

சுருக்கம்

சிட்டினிலிருந்து நாவல் நேரடி சுருக்க பாலிமெரிக் எக்ஸிபியண்ட்ஸ் மற்றும் மருந்துப் பயன்பாடுகளுக்கான அதன் வழித்தோன்றல்கள்

Abu Fara D

Chitin and its derivative were investigated as novel direct compression (DC) excipients for immediate and controlled release applications. In the former, roller compaction technology was employed in a specific manner to convert the low bulk density, poor flowability and low compactibility of chitin powder into a DC excipient. In the latter, a combination of low molecular weight chitosan (LCS) with xanthan gum was found to provide the basis for controlled release preparations. The novel excipients were characterized using XRPD and FTIR tests. Compressibility and compactibility of the powders were examined thereafter using flow indices, Heckel and Kawakita analysis, and force-displacement curve. The novel excipients showed improvement in powder flow, high resistance to compression force, and high extent of plastic deformation. This work further elaborated on the role of LCS in the enhancement of powder compressibility and compacts strengths when mixed at an optimum mass content with the highly fragmenting xanthan gum. Dissolution profiles of metronidazole and metoprolol succinate tablets comprising the novel excipients confirmed their suitability in immediate and controlled release applications.