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Correction of Oxygen-Nutrient Mismatch Might Account for the Beneficial Effect of Obeticholic Acid in NASH

Gerond Lake-Bakaar*

The Farnesoid X Receptor (FXR) is a nuclear bile acid receptor involved in bile acid homeostasis, hepatic and intestinal inflammation, liver fibrosis, and cardiovascular disease. Obeticholic Acid (OCA), a potent, selective FXR agonist decreases portal hypertension in animal models of cirrhosis [1,2]. The drug is also effective in the treatment of non-alcoholic steatohepatitis, NASH [3-5]. The two disparate findings might be reconciled by an effect of OCA on hepatic artery flow.