select ad.sno,ad.journal,ad.title,ad.author_names,ad.abstract,ad.abstractlink,j.j_name,vi.* from articles_data ad left join journals j on j.journal=ad.journal left join vol_issues vi on vi.issue_id_en=ad.issue_id where ad.sno_en='13760' and ad.lang_id='10' and j.lang_id='10' and vi.lang_id='10'
ஐ.எஸ்.எஸ்.என்: 2472-1115
Maryam Zain, Fazli Rabbi Awan and Shahid Mahmood Baig
The Catechol-O-Methyl Transferase (COMT) gene polymorphism (I/D of C nucleotide at base position 900) has been previously associated in the brain disorders and inflammatory reactions but some studies also showed its presence in the development of type 2 diabetes (T2D) and kidney disease. So, the present study aimed to find association of I/D polymorphism with T2D, and its associated factors like family history and nephropathy (End Stage Renal Disease, ESRD) patients in a small group of Pakistani Punjabis.
The results identified a significant (p=0.02) correlation of the 900 I/D C polymorphism with family history of diabetes, as it was found that greater number (74%) of patients having I allele had a positive family history of T2D. This has not been previously reported in Pakistani Punjabi population; however, this preliminary finding requires further validation studies.