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Transient Choroidal Thinning after Intravitreal Bevacizumab Injection for Myopic Choroidal Neovascularization

Kaori Sayanagi, Yukari Jo and Yasushi Ikuno

Purpose: To evaluate the choroidal thickness changes in the eyes with myopic choroidal neovascularization (mCNV) after intravitreal injection of bevacizumab (IVB).
 
Methods: Ten highly myopic eyes with mCNV treated with IVB were included. All patients underwent a single, horizontal B-scan image centered on the fovea, before, and 1 month and 3 month after IVB using Heidelberg optical coherence tomography (OCT). Choroidal thickness (CT) defined as the distance from the retinal pigment epithelium to the chorio-scleral interface in OCT image at the fovea, 2mm nasally and 2mm temporally was measured.
 
Results: Foveal mean CT was 52.8 microns before IVB, and it significantly decreased to 37.5 microns 1 month after (P<0.05). Similarly, the 2mm temporal mean CT was 80.5 microns before IVB, and it significantly decreased to 69.5 microns 1 month after (P<0.05). On 3 months after IVB, mean CT at the fovea improved to 48.9 microns (P=0.67); however, the mean temporal CT remained thin as 67.0 microns (P=0.07 vs. baseline). The mean nasal CT remained at the similar throughout the follow-up (P=0.90 and 0.56) The change in CT on 1 month after IVB was significantly correlated with age and preoperative CT (P=0.01 and 0.04, respectively).
 
Conclusions: Subfoveal and temporal choroidal thinning is transiently observed. IVB may affect the choroidal circulation in such myopic eyes as with thin choroid.