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சுருக்கம்

Sequential Changes in Blood Tetrodotoxin Concentrations in Lethal Puffer Fish Poisoning: A Case Report

Yusuke Okazaki*, Shiori Kobayashi, Nakashima Akie, Yasumasa Iwasaki

Severe symptoms of tetrodotoxin poisoning caused by the ingestion of puffer fish include respiratory muscle paralysis, hypotension, and cardiopulmonary arrest. However, the blood concentration of tetrodotoxin that causes cardiopulmonary arrest remains unknown. We herein present a case of tetrodotoxin poisoning in a 76-year-old man, who died later. We measured the blood tetrodotoxin levels over time in a patient with severe tetrodotoxin poisoning. A 76-year-old man had tetrodotoxin poisoning after consuming three puffer fish. He complained of numbness in his mouth after 10 min and developed cardiopulmonary arrest when ambulance crews arrived 43 min after ingestion. Cardiopulmonary resuscitation was performed, and he had a return of spontaneous circulation shortly before arriving at our hospital. The blood tetrodotoxin concentration was 119 ng/mL after 5 hours. On day 5, he died due to multiple organ failure. Thus, the blood tetrodotoxin concentration causing cardiopulmonary arrest was approximately 100 ng/mL in this case.