மயக்க மருந்து & மருத்துவ ஆராய்ச்சி
திறந்த அணுகல்

சுருக்கம்

Ropivacaine Decreases Tissue Oxygen Saturation Following Peripheral Nerve Block in Children

Nina Deutsch, Mamta Singh, Sophie R. Pestieau, Sean P. Alexander, Domiciano Santos and Richard J. Levy

Background: Local anesthetics can cause vasoconstriction and disrupt neuronal impulses, reducing regional blood flow and increasing tissue oxygen consumption. This could alter regional oxygen supply and demand. Because microcirculation modifies during development and oxygen consumption kinetics differ between children and adults, we aimed to assess effects of ropivacaine Peripheral Nerve Block (PNB) on regional tissue saturation in children and young adults using Near-Infrared Spectroscopy (NIRS).

Methods: Following Institutional Review Board approval and informed consent, 20 patients undergoing PNB for various orthopedic surgeries were studied. NIRS sensors were placed on the operative limb, contralateral limb, and forehead. Tissue saturations (rSO2) were recorded at baseline and every 5 minutes for 60 minutes following ropivacaine PNB. Mean rSO2 was assessed with repeated measures ANOVA. Correlation of tissue rSO2 with cerebral oximetry was calculated and significance determined with student’s t-test.

Results: In all patients, blocked limb rSO2 decreased significantly compared to control limb 20 minutes after injection and remained lower. Control limb rSO2 and cerebral oximetry did not change over time. Non-blocked limb rSO2 demonstrated weak but significant correlation with cerebral oximetry while blocked limb rSO2 showed no correlation. Mean change in blocked limb rSO2 from baseline was significantly negative compared to a net positive mean change in the non-blocked limb.

Conclusions: Decreased rSO2 following PNB suggests reduced local blood flow due to vasoconstriction, increased tissue oxygen consumption, or both. Changes in rSO2 provide an opportunity to develop NIRS as a non-invasive tool to identify successful PNB. Local anesthetic-induced decline in rSO2 could have implications in operative settings with ischemia or low-flow.