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Preliminary Exploration of Structure-Function Crosstalk in Colorectal Cancer Research: Protein Structuromics

Ogori A Friday*, Abu J Oneh, Hwa Dai, Na-Sheng Lin

Colorectal Cancer (CRC) refers to cancer that develops from the colon or rectum (parts of the large intestine). Signs
and symptoms include blood in the stool, changes in bowel movements, weight loss, and fatigue. Since 1923, when
the disease was first named, survival rates have always been unsatisfactory. Despite great advances in molecular
biology and traditional treatment methods, many questions remain to be answered regarding cancer occurrence and
the underlying mechanism. Medical doctors remain stymied regarding tumor recurrence and worsening disease after
effective treatment. To better understand the relevant questions, in this study, 20 oncogenes and 20 anti-oncogenes
were examined in relation to protein structure, from protein structure analysis and dynamic analysis methods to 3D
structure analysis and systematic analysis of the structure‒function relationships of proteins. We hope that these
analyses will help promote mechanistic research and the development of new treatments for CRC