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Pharmacogenetics Variations in Anesthesia

Avinash Puri

Pharmacogenetics is an emerging discipline that attempted to understand the hereditary basis for differences in responsiveness or inter-individual variation to therapeutic agents. It is the study of variability in drug response as a result of heredity factors. The importance for pharmacogenetics for the clinician is to enable optimum therapeutic efficacy, to avoid toxicity of those drugs whose metabolism is catalyzed by polymorphic isoenzymes, and to contribute to the rational design of new drugs.