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Molecular Biology & Biochemistry -2018 The Feasibility of Driving Nucleated Blood Cells to Pluripotency in Cases of Leukemia

Lia Monica Junie

Leukemia are cancers of early blood forming cells found in bone marrow. Acute myeloid and lymphoblastic leukemia are characterized by a rapid increase in the number of immature myeloid and lymphoid cells (blasts), crowding due to such cells makes the bone marrow unable to produce normal blood cells. A stem cell transplant can be used to restore healthy bone marrow in patients with leukemia. Stem cells help stimulate new bone marrow growth and restore the immune system. However, it is limited by the lack of suitable human leukocyte antigen (HLA) matched donors and high rates of transplant-related morbidity and mortality. FiPS: - a new cocktail produced by Royal Biotechnology, Germany, Cat.Nr. RBHD1 is being used to induce cellular stress through methylation and gradual down regulation of gene expression which leads to up-regulation of stemness genes as the last chance to protect from cell death. Deprogramming of cells through methylation drives the cells to a semi-embryonic status.