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LIPC rs10468017, rs493258 and LPL rs12678919 Role in Patients With Age- Related Macular Degeneration

Rasa Liutkeviciene, Alvita Vilkeviciute, Greta Streleckiene, Loresa Kriauciuniene and Vytenis Pranas Deltuva

Objective: Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly individuals in developed countries. The etiology and pathophysiology of AMD are not fully understood. Formation of drusen is the main pathological change in AMD. Lipids make up about 40% of drusen volume, thus possible relation between AMD and genes controlling lipid metabolism could provide novel insights into AMD. Our purpose was to determine the genotype frequencies of LIPC rs10468017, rs493258 and LPL rs126789919 in patients with AMD in Lithuanian population. Methods: The study enrolled 279 patients with early AMD, 256 patients with exudative AMD, and 829 healthy controls (reference group). The genotyping was carried out using the RT-PCR. Results: LIPC rs10468017 polymorphism was associated with a decreased risk of early and exudative AMD, while LPL rs126789919 polymorphism was associated with a decreased risk of exudative AMD and LIPC rs493258 was only associated with a decreased risk of early AMD. Conclusion: The study showed that LIPC rs10468017, rs493258 and LPL rs126789919 gene polymorphisms may have a protective role in AMD development.