என்சைம் பொறியியல்
திறந்த அணுகல்
ஐ.எஸ்.எஸ்.என்: 2329-6674
ஐ.எஸ்.எஸ்.என்: 2329-6674
Masoud Dadashi
Background and Aim: New Delhi Metallo-beta-lactamase (NDM)-producing Escherichia coli (E. coli) is allegedly perceived as one of the most indispensable multidrug-resistant bacteria causing infections in hospitals and clinic domains. The nobility of the present study was evaluation of epidemiology, genotypes and the most prevalent sequence types (STs) of NDM-producing E. coli among clinical isolates worldwide.
Methods: Several international databases including Medline, Embase, and Web of sciences were searched from March 2018 to June 2018 to discern studies addressed the prevalence of NDM-producing E. coli around the world.
Results: Of the 974 records identified from the databases, 110 studies fulfilled the eligibility criteria ostensibly. The analyses manifested that the prevalence of NDM-producing E. coli were 82.6%, 12.9%, 1.4%, 0.9% and 1.9% in Asia, Europe, America, Africa and Oceania continents, respectively. According to our results, the most common reported STs among NDM- producing E. coli were ST101, ST167, ST131, ST405, ST410 and ST648.
Conclusions: The dissemination of NDM variants among E. coli strains is a serious threat to global public health. In addition, the most prevalent E. coli clonal groups such as ST101 and ST167 are one of the main causes of E. coli infection in different countries. Then the control of the spread of NDM variants-producing E. coli especially in the most common E.coli clonal groups, is very important to prevent the spread of antimicrobial resistance around the world.