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Trypanosoma cruzi Antigenic Proteins: Shared with Acute Lymphoblastic Leukemia and Neuroblastoma

Leticia Eligio García, Mariana Soria Guerrero, María del Pilar Crisóstomo Vázquez, Víctor Alberto Maravelez Acosta, Adrián Cortes Campos, Enedina Jimenez Cardoso

An inhibitory relationship has been reported between the incidence of some parasitic infections and the development of cancer. Reported studies show that immunization with protein extracts of T. cruzi, the protozoan parasite that causes Chagas disease, prevents the appearance of tumors in 60% of mice injected with the murine lung carcinoma tumor line. The molecular bases of this process have not been elucidated, although the presence of antigens present in tumor cells and on the surface of T. cruzi suggests an anti-parasitic immune response with an effective cross-reaction against cancer cells, hence the importance to identify the antigens involved and figure out their potential as target cells in anticancer therapy. The general objective of this work is to determine the presence of antigenic proteins of T. cruzi, shared with cells in culture of ALL and NB, for this, polyclonal antibodies against T. cruzi were developed in rabbits, and the reactivity with protein extracts of cultured ALL and NB cells was determined, Likewise, the protein immunodetection of the different strains of T. cruzi was carried out with the anti-T. cruzi antibodies of the five strains. The study would also contribute to broadening the knowledge of immunological interactions between cancer and parasites in the future and therefore would broaden the panorama of new therapeutic strategies applied in oncology.