மயக்க மருந்து & மருத்துவ ஆராய்ச்சி
திறந்த அணுகல்
ஐ.எஸ்.எஸ்.என்: 2155-6148
ஐ.எஸ்.எஸ்.என்: 2155-6148
Hoda Shokri*, Ihab Ali
Background: The aim is to compare the use of adenosine and verapamil for management of postoperative supraventricular tachycardia in terms of time of conversion of SVT to normal sinus rhythm, success rate, hospital stay length and adverse events
Methods: Patients (54–65 years old) received adenosine or verapamil groups. In the adenosine group, patients received IV adenosine 6 mg bolus then wait 2 minutes, if it failed another 12 mg IV of adenosine was administered. In the verapamil group, patients received IV verapamil 5 mg bolus slowly over 2 minutes followed by a second IV bolus of 10 mg, 30 minutes after the initial dose in persistent Supra Ventricular Tachycardia (SVT). If SVT persisted, the patient was shifted to adenosine.
Results: Patients were followed up regarding the efficacy of drug; blood pressure, mean time of conversion of SVT (time elapsed from effective dose of the study drug till conversion of SVT to sinus rhythm) and incidence of adverse events were recorded. The efficacy of adenosine was significantly higher than verapamil (P<0.001). The time of conversion of SVT to sinus rhythm was significantly shorter in adenosine group compared with verapamil group (P<0.001). The incidence of hypotension was comparable between the study groups. The mean arterial blood pressure and the incidence of complications were comparable.
Conclusion: Intravenous administration of adenosine effectively treat SVT in terms of higher efficacy and shorter time of conversion of SVT to normal sinus rhythm compared with verapamil without any significant difference regarding the incidence of side effects between the study groups.
Trial registration: This study was approved by Medical ethics committee of Ain Shams University approval number FMASU R 62/2019) and the protocol was prospectively registered at ClinicalTrials.gov: NCT 04203368 on December 16, 2019.