மயக்க மருந்து & மருத்துவ ஆராய்ச்சி
திறந்த அணுகல்

சுருக்கம்

Effectiveness of Intra-operative Intravenous Lidocaine Infusion as Part of Postoperative Analgesia for Patients Undergoing Abdominal Surgery under General Anesthesia in Addis Ababa Hospitals, Ethiopia 2018: Observational Cohort study

Assefa Hika, Bacha Aberra, Mikael Azanaw, Wesenyeleh Admasu, Degena Bahrey

Introduction: Postoperative pain after abdominal surgery is excruciating, due to the damage of muscles and tissues. The importance of pain relief is well-recognized but it is most often seen that pain control is inadequate. Results of previous study shows the opioid consumption is 70% after abdominal surgery. An increasing amount of evidence suggests that intra-operative intravenous lidocaine infusion can influence pain severity, postoperative analgesic requirement and decrease opioid side effects. Objective: The aim of this study was to assess analgesic effectiveness of intra-operative intravenous lidocaine infusion as part of postoperative analgesia for patients undergoing abdominal surgery under general anesthesia in Addis Ababa Hospitals. Methods: Institutional based prospective cohort study conducted at Addis Ababa Hospitals among sixty eight elective abdominal surgery patients who were grouped into exposed and controlled group based on lidocaine (1mg/kg/hr) given or not. Systematic random sampling was employed. Mann Whitney U test was used to compare median pain score, time to first analgesia request in minutes and total analgesia consumption between groups. Homogeneity of categorical independent variable between two exposure groups was analyzed using Chi Square or Fisher’s exact test. Box and whisker plot were used to show a median pain score differences between groups and p value <0.05 considered as statistical significance with a power of 80%. Result: Demographic characteristics were comparable between the groups, p>0.05. Twenty four hour median VAS score (0-10 cm) at immediate recovery, 3rd, 6th, 12th and 24th hour showing lower median pain score, p<0.05. The median time to first analgesia request in minutes were longer (180 minutes) in exposed group compared to 45 minutes in non-exposed group (p=<0.0001). The median tramadol consumption within 24 hour is 50 mg in exposed group compared to 100 mg in non-exposed group (p<0.0001). Conclusions: Intra-operative lidocaine infusion decreases postoperative pain score, total analgesia consumption and prolongs time to first analgesia request for abdominal surgery done under general anesthesia.