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Centromere and Genome Instability in Patients with Acute Leukemia

Sirenko Artur

The phenomena of Premature Centromere Division (PCD) of metaphase chromosomes and premature anaphase (Canaphase) in 57 patients with Acute Lymphoblastic Leukemia (ALL) and 32 patients with Acute Myeloblastic Leukemia (AML) were investigated. It was found that the levels of PCD and C-anaphase in patients with acute leukemia in the first acute period of the course of the disease in both peripheral blood and red bone marrow significantly exceed these indicators in the control group (healthy blood and red bone marrow donors). During the period of remission, the values of PRC and C-anaphase decreased and approached the values of the control group. The phenomena of PRC and C-anaphase can be used as additional non-specific diagnostic criteria for the course of ALL and AML. A high positive correlation was found between the level of blasts in peripheral blood and the level of PCD in peripheral blood (r=0.890 for ALL, r=0.987 for AML), which suggests that this phenomenon is characteristic to a greater extent of blast cells than of normal lymphocytes. A relationship was revealed-a high positive correlation between the level of aneuploid clones in the peripheral blood of patients with acute leukemia and the level of PCD in the peripheral blood (r=0.832 for ALL; r=0.960 for AML), which suggests that PCD is one of the causes of instability of the genome in acute leukemia’s.