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CD49d and CD26 are Independent Prognostic Markers for Disease Progression in Patients with Chronic Lymphocytic Leukemia

Lamia Ibrahim, Wesam E Elderiny, Loie Elhelw and Mohamed Ismail

Chronic lymphocytic leukemia (CLL) is a clonal expansion of small mature lymphocytes accumulating in blood, bone marrow, and lymphoid organs. CLL is characterized by extremely variable clinical courses with survivals ranging from one to more than 15 years [1]. Rai and Binet clinical staging systems were established for prognostic stratification of these cases [2,3].