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Analyzing the Evolution of Biochemical Reaction System with a Complex Network Based Approach

Shu-Qiang Wang1 and Yan-Yan Shen

Complex network theory has recently been used in System biology, but so far the resulting networks have only been analyzed statically. In this work, the biochemical reaction network (BRN) model is proposed based on the complex network theory and the dynamics of the network is analyzed on the molecular-scale. Given the initial ate and the evolution rules of the biochemical network, we demonstrated how the biochemical reaction network achieving homeostasis. The evolution of the biochemical reaction network is studied in perspective of average degree and edges. Comparing with the network features of random graphs, the network features from the proposed BRN model can reveal more biological sense.