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An Unusual Form of Avellino Dystrophy after Laser in situ keratomileusis: A Late Onset or Recurrence?

Kyung-Sun Na and Man Soo Kim

Purpose: To report an unusual manifestation of a corneal deposit of Avellino corneal dystrophy (ACD) after bilateral, simultaneous laser in situ keratomileusis (LASIK).
 
Methods: A 36-year-old Korean woman who underwent uncomplicated, bilateral LASIK and repeated phototherapeutic keratectomy (PTK) in her left eye due to corneal opacities, showed numerous, fine, white opacities with central corneal stromal haze in the left eye, which was the typical manifestation of the recurrent form of ACD. However, in the right eye, several discrete white opacities were deposited in the central anterial stroma, which was a morphologic feature of the natural course of ACD.
 
Results: The heterozygous R124H (CGC→CAC) mutation of the BIGH3 gene was found in her genomic DNA extraction.
 
Conclusion: Further studies should be focused on what is responsible for the differences of the onset period and the shapes of the deposits in patients with ACD.