ஜர்னல் ஆஃப் கிளினிக்கல் & எக்ஸ்பெரிமென்டல் டெர்மட்டாலஜி ரிசர்ச்
திறந்த அணுகல்
ஐ.எஸ்.எஸ்.என்: 2155-9554
ஐ.எஸ்.எஸ்.என்: 2155-9554
Navneet Kaur Randhawa, Surendra Kumar*, US Agarwal, Puneet Agarwal, Ambika Bansal, Sapna Meena
Background: Plane warts are a common viral infection of skin and mucosa causing significant cosmetic concern to the patient, especially if they are multiple and disseminated over the face.
Objective: To compare the effectiveness and safety of low dose oral isotretinoin (20 mg/day fixed) alone against combination with topical tretinoin (0.1%) in gel formulation for the treatment of verruca plana.
Methods: Two verruca plana treatment approaches were compared in a prospective randomized interventional clinical trial.
Two groups of sixty individuals with numerous plane warts were randomly assigned. Group A received oral isotretinoin capsules at a dose of 20 mg daily, whereas Group B received oral isotretinoin at a dose of 20 mg daily in addition to topical tretinoin 0.1% in gel formulation once daily at night. The patients received treatment for 12 weeks. Patients who had a full recovery were monitored for 8 weeks to track the recurrence rate.
Results: Although the difference was not statistically significant, patients receiving combination therapy had more rapid lesion resolution and a higher total percentage of lesion resolution.
Conclusion: Combination treatment leads to faster and complete resolution of the lesions than oral isotretinoin alone. More trials with large sample size needed.
Limitation: Study sample size was small, that was the only limitation.