select ad.sno,ad.journal,ad.title,ad.author_names,ad.abstract,ad.abstractlink,j.j_name,vi.* from articles_data ad left join journals j on j.journal=ad.journal left join vol_issues vi on vi.issue_id_en=ad.issue_id where ad.sno_en='48307' and ad.lang_id='10' and j.lang_id='10' and vi.lang_id='10'
ஐ.எஸ்.எஸ்.என்: 2155-9899
Stavroula A. Paschou, Stelios Tigas, Katerina Naka, George K. Papadopoulos and Agathocles Tsatsoulis
In this article, we review the role of T regulatory cells (Tregs) in the development and prevention of type 1 diabetes. We first examine the definition of human Tregs, the generation of Tregs in the thymus and the periphery, their mode of action and their important role in the regulation of the immune response. We then examine the defects in Tregs observed thus far in type 1 diabetes and their role in the development of the disease. Finally, we point to possible clinical applications using Tregs as a therapeutic target for the prevention of type 1 diabetes.