select ad.sno,ad.journal,ad.title,ad.author_names,ad.abstract,ad.abstractlink,j.j_name,vi.* from articles_data ad left join journals j on j.journal=ad.journal left join vol_issues vi on vi.issue_id_en=ad.issue_id where ad.sno_en='12001' and ad.lang_id='10' and j.lang_id='10' and vi.lang_id='10' The Association between Vitamin D Receptor FokI Gene Polymor | 12001
ஆஸ்டியோபோரோசிஸ் மற்றும் உடல் செயல்பாடு பற்றிய இதழ்

ஆஸ்டியோபோரோசிஸ் மற்றும் உடல் செயல்பாடு பற்றிய இதழ்
திறந்த அணுகல்

ஐ.எஸ்.எஸ்.என்: 2329-9509

சுருக்கம்

The Association between Vitamin D Receptor FokI Gene Polymorphism and Osteoporosis in Postmenopausal Women: A Meta-Analysis

Jihong Zhang, Zhipeng Ai, Xianming Ning, Hong Liu, Wenru Tang and Ying Luo

Objective: The aim of this study was to quantitatively summarize the evidence for VDR FokI gene polymorphism and osteoporosis risk in postmenopausal women.

Materials and methods: Electronic search at PubMed, EMBASE, Weipu database, and Wanfang database was conducted to select studies. Case-control studies containing available genotype frequencies of F/f were chosen, and Odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of this revelance.

Results: The case-control studies including 2199 osteoporosis cases and 2231 controls were identified. Overall meta-analysis indicated that individuals with the homozygous ff genotype had increased risk of osteoporosis(Recessive model: OR=1.551, 95% CI: 1.035~2.325,p=0.034).In the stratified analysis, individuals with the ff genotype in the Recessive model had increased risk of osteoporosis in Asian subjects(OR=2.644, 95% CI: 1.583~4.419,p= 0.000),but not in Caucasian subjects(OR= 1.288, 95%CI: 0.783~2.118, p = 0.318) and Mixed subjects (OR= 0.885, 95%CI: 0.686~1.141, p =0.346). A symmetric funnel plot, the Begg- test (P=0.094) suggested that lack of publication bias. The studies conducted in each of the defined number of osteoporosis—had no effect of the FokI polymorphism on osteoporosis except for the ff versus Ff+FF genotype comparison for osteoporosis subgroup.

Conclusion: In conclusion, our meta-analysis suggests that VDR Fok I genotype is associated with increased risk of osteoporosis in Asian but not in caucasian. To draw comprehensive and true conclusions, further prospective studies with larger numbers of participants worldwide are needed to examine associations between VDR Fok I polymorphism and osteoporosis.

மறுப்பு: இந்த சுருக்கமானது செயற்கை நுண்ணறிவு கருவிகளைப் பயன்படுத்தி மொழிபெயர்க்கப்பட்டது மற்றும் இன்னும் மதிப்பாய்வு செய்யப்படவில்லை அல்லது சரிபார்க்கப்படவில்லை.
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