select ad.sno,ad.journal,ad.title,ad.author_names,ad.abstract,ad.abstractlink,j.j_name,vi.* from articles_data ad left join journals j on j.journal=ad.journal left join vol_issues vi on vi.issue_id_en=ad.issue_id where ad.sno_en='98458' and ad.lang_id='10' and j.lang_id='10' and vi.lang_id='10' Systemic Sclerosis-Interstitial Lung Disease Characteristics | 98458
நோயெதிர்ப்பு ஆராய்ச்சி

நோயெதிர்ப்பு ஆராய்ச்சி
திறந்த அணுகல்

ஐ.எஸ்.எஸ்.என்: 1745-7580

சுருக்கம்

Systemic Sclerosis-Interstitial Lung Disease Characteristics and Survival Rates in a Long-term Follow-up

Shiri Keret1, Yolanda Braun-Moscovici2,3, Anna Solomonov3,4, Doron Markovits2, Sami Giryes2, Kohava Toledano2,3, Yonit Tavor2, Katya Dolnikov2, Alexander Rozin2,3, Elite Vainer Evgrafov4, Hanna Dawood4, Luda Guralnik3,5, Alexandra Balbir-Gurman2,3*

Objective: To assess the morbidity, mortality and prognostic factors of patients with Systemic Sclerosis (SSc) and Interstitial Lung Disease (ILD).

Methods: A retrospective analysis of prospectively collected data of SSc patients between the years 2000-2020. Data collection included demographic and clinical parameters, with repeated assessments of Forced Vital Capacity (FVC), Diffusing Capacity of the Lungs for Carbon Monoxide (DLCO), and Pulmonary Artery Pressure (PAP) in SSc-ILD patients.

Results: Among 446 SSc patients [367 (82.2%) female, mean age 46.5 years, 175 (39.2%) diffuse SSc [DcSSc]], 141 (31.6%) had SSc-ILD, 121 (27.1%) deceased, of which 74 (61.6%) patients died from SSc-related complication. SSc-ILD was associated with male sex, Arab descent, DcSSc, anti-topoisomerase antibodies, myopathy, and Pulmonary Hypertension (PAH). Mortality in SSc-ILD was associated with older age, Arab descent, and PAH. Elevated PAP estimated by echocardiography at the time of SSc-ILD diagnosis, and rapid decline of FVC or DLCO, correlated with mortality. Five-year survival rates in SSc and SSc-ILD patients were constant.

Conclusion: Arab descent is an important prognostic factor for ILD and mortality. In SSc-ILD, early elevation of PAP and rapid decline in FVC or DLCO indicated a poor prognosis. SSc- related mortality is still high, and has remained stable in recent decades.

மறுப்பு: இந்த சுருக்கமானது செயற்கை நுண்ணறிவு கருவிகளைப் பயன்படுத்தி மொழிபெயர்க்கப்பட்டது மற்றும் இன்னும் மதிப்பாய்வு செய்யப்படவில்லை அல்லது சரிபார்க்கப்படவில்லை.
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