select ad.sno,ad.journal,ad.title,ad.author_names,ad.abstract,ad.abstractlink,j.j_name,vi.* from articles_data ad left join journals j on j.journal=ad.journal left join vol_issues vi on vi.issue_id_en=ad.issue_id where ad.sno_en='20502' and ad.lang_id='10' and j.lang_id='10' and vi.lang_id='10' Role of Leptin in Immune Dysfunction in WNIN Obese Rats | 20502
உட்சுரப்பியல் & வளர்சிதை மாற்ற நோய்க்குறி

உட்சுரப்பியல் & வளர்சிதை மாற்ற நோய்க்குறி
திறந்த அணுகல்

ஐ.எஸ்.எஸ்.என்: 2161-1017

சுருக்கம்

Role of Leptin in Immune Dysfunction in WNIN Obese Rats

Prathibha Bandaru, Hemalatha Rajkumar, Venkata Prasad Upadrasta and Giridharan Nappanveettil

Aim: Role of leptin in bringing about systemic immune response under obesity has so far been speculative. In the present study we addressed this question using genetically obese rats developed at our centre- WNIN/Ob and WNIN/ GR-Ob.

Methodology: Both the lean (+/+) and homozygous obese animals (-/-) received either phosphate buffered saline or leptin. While another set of fed lean and obese served as controls. Effect of leptin on immune function was assessed in terms of splenic lymphocyte proliferative response to Concavalin A (Con A), splenic CD4/CD8 ratio and Nitric oxide (NO) production by macrophages. Further, we also studied if the effect of leptin on immune function was associated with changes in receptor OBR (Leptin receptor) and or JAK2 (Janus tyrosine kinase 2) total protein expression.

Results: Lean animals of both the strains (WNIN/GR-Ob & WNIN/Ob lean) responded to leptin treatment, in terms of increased CD4/CD8 ratio and lipopolysaccharide stimulated peritoneal macrophage Nitric Oxide (NO) production (P<0.05), while splenic lymphocyte proliferative response (P<0.05) to Concavalin A upon leptin treatment was observed only in WNIN/GR-Ob lean animals. Furthermore, significant increase in obese receptor (OBR) protein expression and a trend for JAK2 protein expression (P=0.06) upon leptin treatment were seen in WNIN/GR-Ob and WNIN/Ob lean animals respectively.

Conclusion: The data thus show that leptin resistance could be one of the factors associated with immune dysfunction in obese condition.

மறுப்பு: இந்த சுருக்கமானது செயற்கை நுண்ணறிவு கருவிகளைப் பயன்படுத்தி மொழிபெயர்க்கப்பட்டது மற்றும் இன்னும் மதிப்பாய்வு செய்யப்படவில்லை அல்லது சரிபார்க்கப்படவில்லை.
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