நோயெதிர்ப்பு ஆராய்ச்சி
திறந்த அணுகல்

சுருக்கம்

Base de données de séquences protéiques pour les arénavirus pathogènes

Huynh-Hoa Bui, Jason Botten, Nicolas Fusseder, Valerie Pasquetto, Bianca Mothe, Michael J Buchmeier et Alessandro Sette

Background: Arenaviruses are a family of rodent-borne viruses that cause several hemorrhagic fevers. These diseases can be devastating and are often lethal. Herein, to aid in the design and development of diagnostics, treatments and vaccines for arenavirus infections, we have developed a database containing protein sequences from the seven pathogenic arenaviruses (Junin, Guanarito, Sabia, Machupo, Whitewater Arroyo, Lassa and LCMV). Results: The database currently contains a non-redundant set of 333 protein sequences which were manually annotated. All entries were linked to NCBI and cited PubMed references. The database has a convenient query interface including BLAST search. Sequence variability analyses were also performed and the results are hosted in the database. Conclusion: The database is available at http://epitope.liai.org:8080/projects/arena and can be used to aid in studies that require proteomic information from pathogenic arenaviruses.