select ad.sno,ad.journal,ad.title,ad.author_names,ad.abstract,ad.abstractlink,j.j_name,vi.* from articles_data ad left join journals j on j.journal=ad.journal left join vol_issues vi on vi.issue_id_en=ad.issue_id where ad.sno_en='16072' and ad.lang_id='10' and j.lang_id='10' and vi.lang_id='10' Prediction and Conservancy Analysis of Multiepitope Based Pe | 16072
நோயெதிர்ப்பு ஆராய்ச்சி

நோயெதிர்ப்பு ஆராய்ச்சி
திறந்த அணுகல்

ஐ.எஸ்.எஸ்.என்: 1745-7580

சுருக்கம்

Prediction and Conservancy Analysis of Multiepitope Based Peptide Vaccine Against Merkel Cell Polyomavirus: An Immunoinformatics Approach

Mawadda Abd-Elraheem Awad-Elkareem, Soada Ahmed Osman, Hanaa Abdalla Mohamed, Hadeel Abd-Elrahman Hassan, Ahmed Hamdi Abu-haraz, Khoubieb Ali Abd-elrahman and Mohamed Ahmed Salih

Merkel cell Polyomavirus is non-enveloped, dsDNA virus belonging to Polyomaviridae family linked to an uncommon aggressive skin malignancy. The poor prognosis and limited understanding of disease pathogenesis warrants innovative treatment. In this current study we aim to predict TB cell immunogenic epitopes from the VP1 protein of all merkel cell polyomavirus strain which will aid in effective epitope based vaccine design using immuoinformatics approaches. We retrieved 423 full-length VP1 protein sequences of merkel cell polyomaviruse virus species from the NCBI database. These sequences were analyzed to determine the conserved region and were used to predict the epitopes using the IEDB immunoinformatics algorithms. For B cell three epitope were predicted as peptide vaccine (QEKTVY, KTVYPK, and QEKTVYP). For T cell the predicted Class-I peptides (SLFSNLMPK, LQMWEAISV and LLVKGGVEV) were found to cover the maximum number of MHC I alleles. The highest scoring Class II MHC binding peptides were (IELYLNPRM, ISSLINVHY and INSLFSNLM). Further experiments will need to be undertaken to confirm the potential of these predicted epitopes in a future efficacious vaccine development.

மறுப்பு: இந்த சுருக்கமானது செயற்கை நுண்ணறிவு கருவிகளைப் பயன்படுத்தி மொழிபெயர்க்கப்பட்டது மற்றும் இன்னும் மதிப்பாய்வு செய்யப்படவில்லை அல்லது சரிபார்க்கப்படவில்லை.
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