P U Umennadi, L O Ezenweke and A M Ekwonu
The Pyrazolone was introduced into the drug regimen as a drug for the treatment of some organisms until its resistance to some microbes dominated the scene and the need for further research became necessary. Transition metal complexes of Schiff bases have played a significant role in the field of coordination, inorganic and bioinorganic chemistry as models for biological, analytical and industrial applications. The activity of the 4-benzoyl pyrazolone, its Schiff base and it complex formation with platinum group metals necessitated the investigation of their biological activity. This thesis deals with the synthesis, characterization and in vitro biological studies of platinum metals Schiff bases. 4-benzoyl pyrazolone was synthesized as the Primary ligand and further reacted with 2-hydroxyl aniline to form the first Schiff base and also with 2 nitro aniline to form a second Schiff base. The two Schiff bases, complexed with the chlorides of platinum group metals (PGMs) namely – Ru, Rh, Pd, Os, Ir and Pt and characterized by elemental analyses, melting point/decomposition temperature, and molar conductivity, FTIR, and UV-Vis spectroscopy. The results of the spectroscopic studies revealed that the Schiff base ligands coordinated to platinum metal ions through the (>C=N) nitrogen and phenolic oxygen atoms in the spectra of platinum metals complexes.