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OASL rs10774580 SNP is Associated with Herpes Zoster Infection in Rheumatoid Arthritis

Marowa Hashimoto1*, Keiko Funahashi1,2, Ken Tsumiyama2 , Yoshinori Takashima3 , Toshihisa Maeda3 , Koji Fukuda2 , Shinya Hayashi3 , Ryosuke Kuroda3 , Tsukasa Matsubara1,

Introduction: Herpes Zoster (HZ) is known as a side effect of using biologics in Rheumatoid Arthritis (RA). Incidence of this side effect may be different depending on genetic factors because susceptibility to HZ infection varies by race. Here, we analyzed the statistical relationships of whole genome Single Nucleotide Polymorphisms (SNPs) with HZ infection in biologics-treated RA patients.

Materials and methods: The subjects were 321 Japanese female RA patients (including 56 herpes virus infected patients) using biologics. The relationships of 302,814 SNPs with HZ infection were analyzed using case-control analyses by the Chi-square test. We picked up SNPs (P<10-8) significantly associated with HZ infection. Then, the effects of the SNPs were analyzed by using a multivariate logistic regression analysis adjusted for the age of first biologics administration, disease activity, corticosteroid use and methotrexate use.

Results: Rs10774580 located in 2’-5’-oligoadenylate synthetase like gene (OASL) was significantly associated with HZ infection. The minor allele homozygous carrier was positively associated with HZ infection in multivariate analysis.

Conclusion: We for the first time showed a significant relationship between a genetic factor and HZ infection among RA patients. Rs10774580 may be one of the biomarkers for HZ infection.