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IN-VITRO AND IN-VIVO TRANSDERMAL IONTOPHORETIC DELIVERY OF LISINOPRIL GEL

Ashish Jain, Satish Nayak, Vandana Soni

The feasibility of transdermal delivery of Lisinopril gel by cathodal iontophoresis using Ag/AgCl electrode was investigated. A polymer gel was prepared using hydroxypropyl methyl cellulose and in vitro skin permeability was assessed in full thickness skin of rabbits and pigs. For in vivo studies New Zealand rabbits were used. In vitro passive permeation was carried out in Franz diffusion cell but for iontophoresis, diffusion cell was modified according to Glikfield design. For in-vitro study 0.5 mA/cm2 current density was used in iontophoresis with passive controls but for in vivo study current density was reduced to 0.1 mA/cm2. High performance liquid chromatography was used for analysis of drug content in blood samples Blood samples. Results of the in vitro study indicated that iontophoresis considerably increased the permeation rate of Lisinopril compared to passive controls in both the skin types (P<0.01). The plasma concentration of Lisinopril was significantly higher (P<0.001) than that obtained in the passive controls. Results showed that the target permeation rates for Lisinopril could be achieved with the aid of iontophoresis by increasing the area in an appreciable range