select ad.sno,ad.journal,ad.title,ad.author_names,ad.abstract,ad.abstractlink,j.j_name,vi.* from articles_data ad left join journals j on j.journal=ad.journal left join vol_issues vi on vi.issue_id_en=ad.issue_id where ad.sno_en='93720' and ad.lang_id='10' and j.lang_id='10' and vi.lang_id='10' Interactive Role of Cyp2c9 Rs4918758 Polymorphism and Sex in | 93720
மருத்துவ வேதியியல் மற்றும் ஆய்வக மருத்துவ இதழ்

மருத்துவ வேதியியல் மற்றும் ஆய்வக மருத்துவ இதழ்
திறந்த அணுகல்

சுருக்கம்

Interactive Role of Cyp2c9 Rs4918758 Polymorphism and Sex in Ischemic Stroke Susceptibilit

Jui-Wen Peng1, Oswald Ndi Nfor 2, Chien Chang Ho3,4, Shu-Yi Hsu3, Ming-Chih Chou1*, Yung-Po Liaw 2,5

Stroke is a complex health condition caused by several factors. We assessed the possible interaction of the Cytochrome P450 2C9 (CYP2C9) rs4918758 polymorphism with sex in triggering an ischemic stroke. We included 9,197 women and 8,625 men from the Taiwan Biobank (TWB). Data collected between 2008 and 2015 were linked to records in the National Health Insurance Database (NHIRD). We estimated Odds Ratios (OR) for ischemic stroke using logistic regression analysis. We found that ischemic stroke was present in 441 women and 468 men had. Combined TC+CC of rs4918758 did not enhance ischemic stroke risk [OR (95% CI)=1.04 (0.90-1.21]. Compared to women, men did not confer risk for ischemic stroke ([OR (95% CI)=1.03 (0.87-1.22]. There was an interaction between sex and rs4918758 polymorphism (p for interaction=0.0019). After categorizing by sex, significant odds ratios were found in men with combined TT+CC of rs4918758 but not women [OR, 1.32 (1.07-1.63) vs. 0.83 (0.68-1.02)]. Further stratification by genotypes of rs4918758 polymorphism, TT was protective against ischemic stroke [0.59 (0.44-0.80)] in men compared to women. However, combined TT+CC was causative [1.36 (1.10-1.68)]. Our analyses indicated that TT of rs4918758 was protective whereas combined TT+CC appeared to enhance ischemic stroke risk in Taiwanese men compared to women. This study extends knowledge on the genetic basis of ischemic stroke.

மறுப்பு: இந்த சுருக்கமானது செயற்கை நுண்ணறிவு கருவிகளைப் பயன்படுத்தி மொழிபெயர்க்கப்பட்டது மற்றும் இன்னும் மதிப்பாய்வு செய்யப்படவில்லை அல்லது சரிபார்க்கப்படவில்லை.
Top