select ad.sno,ad.journal,ad.title,ad.author_names,ad.abstract,ad.abstractlink,j.j_name,vi.* from articles_data ad left join journals j on j.journal=ad.journal left join vol_issues vi on vi.issue_id_en=ad.issue_id where ad.sno_en='67720' and ad.lang_id='10' and j.lang_id='10' and vi.lang_id='10' Immunoinformatics. | 67720
நோயெதிர்ப்பு ஆராய்ச்சி

நோயெதிர்ப்பு ஆராய்ச்சி
திறந்த அணுகல்

ஐ.எஸ்.எஸ்.என்: 1745-7580

சுருக்கம்

Immunoinformatics.

Aniekan Jumbo*

Clostridium perfringens is a member of the gastrointestinal tract (GIT) microbial community of both diseased and healthy humans and animals. Also, this bacterium is responsible for around 5–15% of all circumstances of antibiotic-associated diarrhea, which develops in 5–40% of all patients receiving antibiotic therapy. In addition, it causes enteritis necroticans; an often-fatal human disease. C. perfringens is clear anddefined the underlying factors responsible for specific aspects of pathology remains uncertain. This study predicts an effective epitope-based vaccine against fructose 1,6-biphosphatealdolase (FBA) enzyme of Clostridium perfringens using immunoinformatics tools. The sequences were retrieved from NCBI and several prediction tests were conducted to analyze possibleepitopes forB-cell,T-cellMHCclass IandII.Tertiary structure of the most promising epitopes was obtained. 48 epitopes showed high binding affinity for B-cells, while five epitopes showed high binding affinity for MHCI and MHCII. The results were promising to formulate a vaccine with more than 98% population coverage. We hope that these promising epitopes serves as a preventive measure for the disease in the future and recommend in vivo and in vitro studies.

மறுப்பு: இந்த சுருக்கமானது செயற்கை நுண்ணறிவு கருவிகளைப் பயன்படுத்தி மொழிபெயர்க்கப்பட்டது மற்றும் இன்னும் மதிப்பாய்வு செய்யப்படவில்லை அல்லது சரிபார்க்கப்படவில்லை.
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